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Numerical simulation of drug eluting coronary stents: Mechanics, fluid dynamics and drug release

Zunino, P; D'Angelo, C; Petrini, L; Vergara, C; Capelli, C; Migliavacca, F; (2009) Numerical simulation of drug eluting coronary stents: Mechanics, fluid dynamics and drug release. In: COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING. (pp. 3633 - 3644). ELSEVIER SCIENCE SA

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Abstract

Mathematical models and numerical methods have emerged as fundamental tools in the investigation of life sciences. In particular, this is the case of medical devices as cardiovascular drug eluting stents, where experimental/clinical evidence may often be very expensive and extremely variable. Here, we present a complete overview of mathematical models and numerical methods applied to the modelling of drug eluting stents and of their interaction with the coronary arteries. This is a challenging task because it involves mechanics, fluid dynamics and mass transfer processes. In particular, we will focus on the importance of the interplay between all these factors to determine the efficacy of the device. (C) 2008 Elsevier B.V. All rights reserved.

Type:Proceedings paper
Title:Numerical simulation of drug eluting coronary stents: Mechanics, fluid dynamics and drug release
Event:Minisymposium on Models and Methods in Computational Vascular and Cardiovascular Mechanics held at the 9th US National Congress on Computational Mechanics
Location:San Francisco, CA
Dates:2007-07-22 - 2007-07-26
DOI:10.1016/j.cma.2008.07.019
Keywords:Mechanical wall/stent interaction, Hemodynamics, Mass transfer, Coupled problems, Finite elements, Medical devices, FINITE-ELEMENT-METHOD, DIFFUSION-REACTION PROBLEMS, ARTERIAL-WALLS, BLOOD-FLOW, TRANSPORT, MODEL, DELIVERY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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