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Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugs

Marks, DJB; Dheda, K; Dawson, R; Ainslie, G; Miller, RF; (2009) Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugs. INT J STD AIDS , 20 (5) 339 - 345. 10.1258/ijsa.2008.008361.

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Abstract

This study investigated whether serious adverse events (SAEs) during antituberculosis therapy occur more frequently in HIV co-infected patients in a South African population. A retrospective analysis examined incidences of hepatotoxicity, peripheral neuropathy, severe arthralgia, persistent vomiting and severe rash in 400 patients treated for tuberculosis in a community clinic. A total of 141 patients were co-infected with HIV, among whom only 16.3% were receiving antiretrovirals. Details of SAEs were ascertainable in 331/400 patients, and occurred in 26.7% of HIV-infected and 13.3% of HIV-uninfected individuals (P = 0.003). The excess was attributable to increased peripheral neuropathy (8.3% and 1.9%, respectively, P = 0.009) and persistent vomiting (13.3% and 3.3%, P = 0.001). SAE occurrence was not related to antiretroviral use, although median CD4 counts were lower in those experiencing side-effects (130 and 259 cells/mu L, P = 0.008). The treatment completion did not differ significantly between the two groups (76.6% and 84.2%, P = 0.08).

Type: Article
Title: Adverse events to antituberculosis therapy: influence of HIV and antiretroviral drugs
DOI: 10.1258/ijsa.2008.008361
Keywords: tuberculosis, HIV, adverse events, neuropathy, South Africa, LATENT TUBERCULOSIS INFECTION, SUB-SAHARAN AFRICA, SOUTH-AFRICA, HEPATOTOXICITY, ERA, PYRAZINAMIDE, RIFAMPIN, OUTCOMES, BURDEN, DEATH
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/1306979
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