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Axon diameter mapping in the presence of orientation dispersion using diffusion MRI

ZHANG, H; Hubbard, PL; Parker, GJM; Alexander, DC; (2011) Axon diameter mapping in the presence of orientation dispersion using diffusion MRI. In: Abbott, DF and Ackermann, JH, (eds.) Proceedings of the International Society for Magnetic Resonance in Medicine (ISMRM 2011): 19th Annual Meeting and Exhibition. (pp. 74 - 74). ISMRM: Berkeley, US. Green open access

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Abstract

Axon diameter mapping using diffusion MRI provides more specific biomarkers than DTI indices. Earlier works assume a model of strictly parallel axons. However, such approximation is inadequate for most white matter regions in which axons fan or bend, resulting in significant orientation dispersion. Such dispersion, if unaccounted for, leads to overestimation of axon diameters. We ameliorates this problem by proposing a model that captures orientation dispersion explicitly. We demonstrate that recovery of axon diameters is possible even in the presence of orientation dispersion, supporting accurate axon diameter mapping in a much wider set of white matter than previously possible

Type:Proceedings paper
Title:Axon diameter mapping in the presence of orientation dispersion using diffusion MRI
Open access status:An open access version is available from UCL Discovery
Publisher version:http://www.ismrm.org/11/index.htm
Language:English
Additional information:19th Annual Meeting & Exhibition held at Montreal, Canada between 7-13 May 2011
Keywords:Axon diameter, diffusion MRI, orientation dispersion
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science

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