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Lipoprotein particle subclasses, cardiovascular disease and HIV infection

Duprez, DA; Kuller, LH; Tracy, R; Otvos, J; Cooper, DA; Hoy, J; Neuhaus, J; ... INSIGHT SMART Study Grp, ; + view all (2009) Lipoprotein particle subclasses, cardiovascular disease and HIV infection. ATHEROSCLEROSIS , 207 (2) 524 - 529. 10.1016/j.atherosclerosis.2009.05.001.

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Abstract

Objective: To study the association of lipoprotein particles with CVD in a subgroup of HIV-infected patients who were enrolled in the Strategies for Management of Anti-Retroviral Therapy (SMART) study. SMART was a trial of intermittent use of ART (drug conservation [DC]) versus continuous of ART (viral suppression [VS]).Methods: In a nested case-control study, lipoprotein particles (p) by nuclear magnetic resonance were measured at baseline and at the visit prior to the CVD event (latest levels) for 248 patients who had a CVD event and for 480 matched controls. Odds ratios (ORs) were estimated using conditional logistic models.Results: Total, large and small HDL-p, but not VLDL-p nor LDL-p, were significantly and inversely associated with CVD and its major component, non-fatal coronary heart disease. The HDL-p associations with CVD were reduced after adjustment for high sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and D-dimer. Latest levels of total HDL-p were also significantly inversely associated with CVD; treatment interruption led to decrease of total HDL-p; adjusting for latest HDL-p did not explain the greater risk of CVD that was observed in the DC versus VS group.Conclusions: Lipoprotein particles, especially lower levels of small and large HDL-p identify HIV-infected patients at increased risk of CVD independent of other CVD risk factors. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: Lipoprotein particle subclasses, cardiovascular disease and HIV infection
DOI: 10.1016/j.atherosclerosis.2009.05.001
Keywords: Atherosclerosis, Cardiovascular disease, Cholesterol, Ischemic heart disease, HDL- and LDL-cholesterol, HIV, Lipids, Lipoprotein particle size and number, MAGNETIC-RESONANCE-SPECTROSCOPY, LOW-DENSITY-LIPOPROTEIN, CORONARY-HEART-DISEASE, ANTIRETROVIRAL THERAPY, RISK, TRIAL, INTERRUPTION, METABOLISM, COHORT, SIZE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/1305988
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