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EXCLUSION FROM PROXIMAL 11Q OF A COMMON GENE WITH MEGAPHENIC EFFECT ON ATOPY

WATSON, M; LAWRENCE, S; COLLINS, A; BEASLEY, R; DOULL, I; BEGISHVILI, B; LAMPE, F; ... MORTON, NE; + view all (1995) EXCLUSION FROM PROXIMAL 11Q OF A COMMON GENE WITH MEGAPHENIC EFFECT ON ATOPY. ANN HUM GENET , 59 403 - 411.

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Abstract

We have typed three markers on proximal 11q in 131 random families with thr ee or more children studied for atopy. A summary map that includes the FCER1B candidate was constructed. Using a 2-locus disease model, rye performed combined segregation and linkage analysis of three models, none of which suggested linkage. Nine marker loci on other chromosomes were also negative. In the regions swept by these 12 markers we cannot rule out a rare gene, perhaps of large effect, nor a common gene of small effect. However, a common gene of large effect is excluded. These results and alternative strategies are discussed in the perspective of inconsistent evidence for a major atopy gene.

Type: Article
Title: EXCLUSION FROM PROXIMAL 11Q OF A COMMON GENE WITH MEGAPHENIC EFFECT ON ATOPY
Keywords: DINUCLEOTIDE REPEAT POLYMORPHISM, IMMUNOGLOBULIN-E, LINKAGE, CHROMOSOME-11Q, LOCUS, ASTHMA, RESPONSES, MAPS
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care > Infection and Population Health
URI: http://discovery.ucl.ac.uk/id/eprint/1305973
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