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Group I mGluR Agonist-Evoked Long-Term Potentiation in Hippocampal Oriens Interneurons

Le Duigou, C; Kullmann, DM; (2011) Group I mGluR Agonist-Evoked Long-Term Potentiation in Hippocampal Oriens Interneurons. J NEUROSCI , 31 (15) 5777 - 5781. 10.1523/JNEUROSCI.6265-10.2011. Gold open access

Abstract

Several subtypes of interneurons in the feedback circuit in stratum oriens of the hippocampus exhibit NMDA receptor-independent long-term potentiation (LTP) at glutamatergic synapses made by local pyramidal neurons. LTP has been reported with both "Hebbian" and "anti-Hebbian" induction protocols, where high-frequency presynaptic stimulation is paired with either postsynaptic depolarization or hyperpolarization. Do these phenomena represent distinct forms of plasticity, dependent on group I metabotropic receptors (mGluRs) and rectifying Ca2+-permeable AMPA receptors, respectively? Blockade of either mGluR1 or mGluR5 prevented anti-Hebbian LTP induction in stratum oriens interneurons in rat hippocampal slices. Exogenous activation of group I mGluRs by the selective agonist (S)-3,5-dihydroxyphenylglycine (DHPG) was unable to induce LTP on its own, and instead depressed excitatory transmission. However, when paired with postsynaptic hyperpolarization, DHPG or the group I metabotropic receptor (mGluR5)-selective agonist (R, S)-2-chloro-5-hydroxyphenylglycine (CHPG) elicited a delayed long-lasting potentiation, which was accompanied by a decrease in paired-pulse facilitation. Anti-Hebbian LTP occluded the effect of DHPG paired with hyperpolarization, implying that the induction cascades triggered by both conjunctions of stimuli converge on common expression mechanisms.

Type: Article
Title: Group I mGluR Agonist-Evoked Long-Term Potentiation in Hippocampal Oriens Interneurons
Open access status: An open access publication
DOI: 10.1523/JNEUROSCI.6265-10.2011
Publisher version: http://ukpmc.ac.uk/abstract/MED/21490219
Keywords: METABOTROPIC GLUTAMATE RECEPTORS, EXCITATORY SYNAPSES, INHIBITORY INTERNEURONS, SYNAPTIC PLASTICITY, RAT HIPPOCAMPUS, INDUCTION, AMYGDALA, CIRCUIT, INPUT, LTP
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy
URI: http://discovery.ucl.ac.uk/id/eprint/1305080
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