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mTOR beta Splicing Isoform Promotes Cell Proliferation and Tumorigenesis

Panasyuk, G; Nemazanyy, I; Zhyvoloup, A; Filonenko, V; Davies, D; Robson, M; Pedley, RB; ... Gout, I; + view all (2009) mTOR beta Splicing Isoform Promotes Cell Proliferation and Tumorigenesis. J BIOL CHEM , 284 (45) 30807 - 30814. 10.1074/jbc.M109.056085. Gold open access

Abstract

The mTOR (mammalian target of rapamycin) promotes growth in response to nutrients and growth factors and is deregulated in numerous pathologies, including cancer. The mechanisms by which mTOR senses and regulates energy metabolism and cell growth are relatively well understood, whereas the molecular events underlining how it mediates survival and proliferation remain to be elucidated. Here, we describe the existence of the mTOR splicing isoform, TOR beta, which, in contrast to the full-length protein(mTOR beta), has the potential to regulate the G(1) phase of the cell cycle and to stimulate cell proliferation. mTOR beta is an active protein kinase that mediates downstream signaling through complexing with Rictor and Raptor proteins. Remarkably, overexpression of mTOR beta transforms immortal cells and is tumorigenic in nude mice and therefore could be a proto-oncogene.

Type: Article
Title: mTOR beta Splicing Isoform Promotes Cell Proliferation and Tumorigenesis
Open access status: An open access publication
DOI: 10.1074/jbc.M109.056085
Keywords: MAMMALIAN TARGET, RAPAMYCIN, PHOSPHORYLATION, PATHWAY, KINASE, RAPTOR, LOCALIZATION, COMPLEX, CANCER, RICTOR
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: http://discovery.ucl.ac.uk/id/eprint/1305059
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