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Diacylglycerol acyltransferases: Potential roles as pharmacological targets

Zammit, VA; Buckett, LK; Turnbull, AV; Wure, H; Proven, A; (2008) Diacylglycerol acyltransferases: Potential roles as pharmacological targets. PHARMACOL THERAPEUT , 118 (3) 295 - 302. 10.1016/j.pharmthera.2008.03.010.

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Abstract

Triglyceride (TG) synthesis occurs in many cell-types, but only the adipocyte is specialised for TG storage. The increased incidence of obesity and its attendant pathologies have increased interest in pharmacological strategies aimed at inhibition of triglyceride synthesis. In the liver this would also appear to offer the advantages of the prevention of steatosis and/or dyslipidaemia. The two major enzymes that have DGAT activity appear to have specialised functions, that are most evident in triglyceride-secreting tissues. The presence of triglyceride in non-adipose cells can lead to (through lipolysis), or be a marker for, undesirable complications such as insulin resistance, or can be indicative of simultaneously high capacities for triglyceride synthesis, lipolysis and oxidation of fatty acids as in highly aerobic, trained muscle. Consequently, inhibition of triglyceride synthesis may not be a straightforward strategy, either in terms of its achievement pharmacologically or in its anticipated outcomes. The metabolic complexities of triglyceride synthesis, with particular reference to the diacylglycerol acyltransferases (DGATs) are considered in this short review. (C) 2008 Elsevier Inc. All rights reserved.

Type:Article
Title:Diacylglycerol acyltransferases: Potential roles as pharmacological targets
DOI:10.1016/j.pharmthera.2008.03.010
Keywords:triglycerides, diacylglycerol acyltransferases, liver, adipose tissue, lipoproteins, secretion, LOW-DENSITY LIPOPROTEIN, INDUCED INSULIN-RESISTANCE, WHITE ADIPOSE-TISSUE, FATTY-ACID SYNTHESIS, TRIGLYCERIDE SYNTHESIS, ACYL-COA, TRIACYLGLYCEROL SYNTHESIS, SKELETAL-MUSCLE, ENDOPLASMIC-RETICULUM, CARNITINE ACYLTRANSFERASES
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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