Abela, R; Ivanova, S; Lidder, S; Morris, R; Hamilton, G; (2009) An Analysis Comparing Open Surgical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis. EUR J VASC ENDOVASC , 38 (6) 666 - 675. 10.1016/j.ejvs.2009.08.002.
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Objective: Endovascular revascularization in atherosclerotic renal artery stenosis (ARAS) has dominated during the last 15 years with surgery relegated mostly to back-up for failed endovascular procedures. This study examines the available outcome evidence to determine what rote open surgery should have in comparison to endovascular treatment in the management of ARAS.Method: Of 183 papers Listed in PubMed, the USNLM and the Cochrane library, (1975-2004) 47, dealing with outcomes of surgical and endovascular treatments (evidence levels 2b and 3) were selected. Endovascular included 1750 patients in 16 prospective non-randomised (PNRT) and 5 retrospective (RET) studies. Surgical included 2314 patients in 4 PNRTs and 17 RETs. Outcome data were subjected to meta-regression analysis weighted according to the inverse variance method.Results: Mean maximum ages were 79.4 yrs (SD 6.9) for surgical and 83.6 yrs (SD 3.8) for endovascutar studies. Primary technical success was similar. Endovascular patency declined by 0.26%/month (95% CI: 0.04-0.48, p = 0.03). Surgical studies showed greater improvement for hypertension control by 21% (95% CI: 9-33%, p = 0.001) and for renal function by 34% (95% CI: 18-54%, p < 0.001), as well as a higher creatinine reduction by 32 mu mol/L (95% CI: 7-57 mu mol/L, p < 0.014). A higher excess surgical mortality, 3.1% (95% CI: 1.8-4.4%, p < 0.001) became insignificant, 0.18% (95% CI: 0.7-1.1, p = 0.70) when concomitant aortic surgery was excluded.Conclusion: This data shows a marked and durable clinical benefit for surgery. These findings question the endovascutar predominance in intervention in ARAS and highlight the need for a carefully designed prospective randomised comparison to define the roles of endovascular and surgical renal revascularization. (C) 2009 European Society for Vascular Surgery. Published by Elsevier Ltd. ALL rights reserved.
|Title:||An Analysis Comparing Open Surgical and Endovascular Treatment of Atherosclerotic Renal Artery Stenosis|
|Keywords:||Atherosclerotic renal artery stenosis, Surgical revascularization, Stent revascularization, Hypertension, Renal function, RENOVASCULAR DISEASE, STENT PLACEMENT, BLOOD-PRESSURE, FOLLOW-UP, ISCHEMIC NEPHROPATHY, REVASCULARIZATION, HYPERTENSION, PRESERVATION, ANGIOPLASTY, FAILURE|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
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