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Lysosome-related organelles: driving post-Golgi compartments into specialisation

Raposo, G; Marks, MS; Cutler, DF; (2007) Lysosome-related organelles: driving post-Golgi compartments into specialisation. CURR OPIN CELL BIOL , 19 (4) 394 - 401. 10.1016/j.ceb.2007.05.001.

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Abstract

Some cells harbour specialised lysosome-related organelles (LROs) that share features of late endosomes/lysosomes but are functionally, morphologically and/or compositionally distinct. Ubiquitous trafficking machineries cooperate with cell type specific cargoes to produce these organelles. Several genetic diseases are caused by dysfunctional LRO formation and/or motility. Many genes affected by these diseases have been recently identified, revealing new cellular components of the trafficking machinery. Current research reveals how the products of these genes cooperate to generate LROs and how these otherwise diverse organelles are related by the mechanisms through which they form.

Type:Article
Title:Lysosome-related organelles: driving post-Golgi compartments into specialisation
DOI:10.1016/j.ceb.2007.05.001
Keywords:WEIBEL-PALADE BODIES, HERMANSKY-PUDLAK-SYNDROME, IMMUNOLOGICAL SYNAPSE, MELANOSOME BIOGENESIS, SECRETORY LYSOSOMES, ENDOTHELIAL-CELLS, P-SELECTIN, PROTEIN, COMPLEX, TRAFFICKING

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