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Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane

Riddell, DR; Sun, XM; Stannard, AK; Soutar, AK; Owen, JS; (2001) Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. J LIPID RES , 42 (6) 998 - 1002. Gold open access

Abstract

The LDL receptor (LDL-R) promotes the specific endocytosis and lysosomal delivery of extracellular lipoprotein ligands via clathrin-coated pits. It was widely assumed that other closely related members of the LDLR gene family would have similar functions, but recent experimental evidence has revealed that one such protein, apolipoprotein E receptor 2 (apoER2), has a critical role as an "outside-in" signal transducer in the brain. ApoER2 signaling appears to require interaction between its cytoplasmic domain and adapter molecules such as Dab1,JIP1 and JIP2, and PSD-95, Many of the receptors for other signaling pathways affected by such adapter molecules are compartmentalized into specialized microdomains within the plasma membrane termed caveolae. Here, we show that apoER2, but not LDL-R, is localized to caveolae, supporting the concept that its physiological role is in cell signaling, rather than in endocytosing ligands. - Riddell, D. R., X-M. Sun, A. K. Stannard, A. K. Soutar; and J. S. Owen. Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane.

Type:Article
Title:Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane
Open access status:An open access publication
Publisher version:http://www.jlr.org/papbyrecent.shtml
Keywords:intracellular signaling, lipid raft, LDL-R family, LRP8, DENSITY-LIPOPROTEIN RECEPTOR, IDENTIFICATION, EXPRESSION, CELLS, GENE, PROTEINS, VESICLES, DOMAINS, FAMILY, APOER2
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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