Leung, KK and Barnes, J and Modat, M and Ridgway, GR and Bartlett, JW and Fox, NC and Ourselin, S and Alzheimers Dis Neuroimaging Initia, (2011) Brain MAPS: An automated, accurate and robust brain extraction technique using a template library. NEUROIMAGE , 55 (3) 1091 - 1108. 10.1016/j.neuroimage.2010.12.067.
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Whole brain extraction is an important pre-processing step in neuroimage analysis. Manual or semi-automated brain delineations are labour-intensive and thus not desirable in large studies, meaning that automated techniques are preferable. The accuracy and robustness of automated methods are crucial because human expertise may be required to correct any suboptimal results, which can be very time consuming. We compared the accuracy of four automated brain extraction methods: Brain Extraction Tool (BET), Brain Surface Extractor (BSE), Hybrid Watershed Algorithm (HWA) and a Multi-Atlas Propagation and Segmentation (MAPS) technique we have previously developed for hippocampal segmentation. The four methods were applied to extract whole brains from 682 1.5 T and 157 3 T T-1-weighted MR baseline images from the Alzheimer's Disease Neuroimaging Initiative database. Semi-automated brain segmentations with manual editing and checking were used as the gold-standard to compare with the results. The median Jaccard index of MAPS was higher than HWA, BET and BSE in 1.5 land 3 T scans (p < 0.05, all tests), and the 1st to 99th centile range of the Jaccard index of MAPS was smaller than HWA, BET and BSE in 1.5 T and 3 T scans ( p < 0.05, all tests). HWA and MAPS were found to be best at including all brain tissues (median false negative rate <= 0.010% for 1.5 T scans and <= 0.019% for 3 T scans, both methods). The median Jaccard index of MAPS were similar in both 1.5 T and 3 T scans, whereas those of BET, BSE and HWA were higher in 1.5 T scans than 3 T scans (p < 0.05, all tests). We found that the diagnostic group had a small effect on the median Jaccard index of all four methods. In conclusion, MAPS had relatively high accuracy and low variability compared to HWA, BET and BSE in MR scans with and without atrophy. (C) 2010 Elsevier Inc. All rights reserved.
|Title:||Brain MAPS: An automated, accurate and robust brain extraction technique using a template library|
|Keywords:||Automated brain extraction, Skull-stripping, Segmentation, MAPS, BET, BSE, HWA, MR-IMAGES, SEGMENTATION, ATLAS, ALGORITHMS, VALIDATION, MODEL|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Imaging Neuroscience|
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Neurodegenerative Diseases
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering
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