UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

An automatic method for assessing structural importance of amino acid positions

Sadowski, MI; Jones, DT; (2009) An automatic method for assessing structural importance of amino acid positions. BMC STRUCT BIOL , 9 (10) 10.1186/1472-6807-9-10.

Full text not available from this repository.

Abstract

Background: A great deal is known about the qualitative aspects of the sequence-structure relationship, for example that buried residues are usually more conserved between structurally similar homologues, but no attempts have been made to quantitate the relationship between evolutionary conservation at a sequence position and change to global tertiary structure. In this paper we demonstrate that the Spearman correlation between sequence and structural change is suitable for this purpose.Results: Buried residues, bends, cysteines, prolines and leucines were significantly more likely to occupy positions highly correlated with structural change than expected by chance. Some buried residues were found to be less informative than expected, particularly residues involved in active sites and the binding of small molecules.Conclusion: The correlation-based method generates predictions of structural importance for superfamily positions which agree well with previous results of manual analyses, and may be of use in automated residue annotation piplines. A PERL script which implements the method is provided.

Type: Article
Title: An automatic method for assessing structural importance of amino acid positions
DOI: 10.1186/1472-6807-9-10
Keywords: SECONDARY STRUCTURE, PROTEIN SEQUENCES, EVOLUTION, FEATURES, FAMILY, PREDICTION, RESOURCES, SELECTION, RESIDUES, MATRICES
UCL classification: UCL > School of BEAMS > Faculty of Engineering Science
UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/130207
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item