UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer

Gibbs, M; Chakrabarti, L; Stanford, JL; Goode, EL; Kolb, S; Schuster, EF; Buckley, VA; ... Ostrander, EA; + view all (1999) Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer. pp. 1087-1095.

Full text not available from this repository.

Abstract

One hundred fifty-two families with prostate cancer were analyzed for linkage to markers spanning a 20-cM region of 1q42.2-43, the location of a putative prostate cancer-susceptibility locus (PCAP). No significant evidence for linkage was found, by use of both parametric and nonparametric tests, in our total data set, which included 522 genotyped affected men. Rejection of linkage may reflect locus heterogeneity or the confounding effects of sporadic disease in older-onset cases; therefore, pedigrees were stratified into homogeneous subsets based on mean age at diagnosis of prostate cancer and number of affected men. Analyses of these subsets also detected no significant evidence for linkage, although LOD scores were positive at higher recombination fractions, which is consistent with the presence of a small proportion of families with linkage. The most suggestive evidence of linkage was in families with at least five affected men (nonparametric linkage score of 1.2; P=.1). If heterogeneity is assumed, an estimated 4%-9% of these 152 families may show linkage in this region. We conclude that the putative PCAP locus does not account for a large proportion of these families with prostate cancer, although the linkage of a small subset is compatible with these data.

Type: Article
Title: Analysis of chromosome 1q42.2-43 in 152 families with high risk of prostate cancer
Additional information: Gibbs, M Chakrabarti, L Stanford, J L Goode, E L Kolb, S Schuster, E F Buckley, V A Shook, M Hood, L Jarvik, G P Ostrander, E A 5T32CA09168/CA/NCI NIH HHS/United States R01CA56678/CA/NCI NIH HHS/United States Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. United states American journal of human genetics Am J Hum Genet. 1999 Apr;64(4):1087-95. One hundred fifty-two families with prostate cancer were analyzed for linkage to markers spanning a 20-cM region of 1q42.2-43, the location of a putative prostate cancer-susceptibility locus (PCAP). No significant evidence for linkage was found, by use of both parametric and nonparametric tests, in our total data set, which included 522 genotyped affected men. Rejection of linkage may reflect locus heterogeneity or the confounding effects of sporadic disease in older-onset cases; therefore, pedigrees were stratified into homogeneous subsets based on mean age at diagnosis of prostate cancer and number of affected men. Analyses of these subsets also detected no significant evidence for linkage, although LOD scores were positive at higher recombination fractions, which is consistent with the presence of a small proportion of families with linkage. The most suggestive evidence of linkage was in families with at least five affected men (nonparametric linkage score of 1.2; P=.1). If heterogeneity is assumed, an estimated 4%-9% of these 152 families may show linkage in this region. We conclude that the putative PCAP locus does not account for a large proportion of these families with prostate cancer, although the linkage of a small subset is compatible with these data.
Keywords: Age Factors Age of Onset Aged Chromosomes, Human, Pair 1/*genetics Ethnic Groups/genetics Family Health Female Genetic Heterogeneity Genetic Predisposition to Disease/*genetics Genotype Haplotypes/genetics Humans Lod Score Male Microsatellite Repeats/genetics Middle Aged Polymorphism, Genetic/genetics Prostatic Neoplasms/diagnosis/epidemiology/*genetics Statistics, Nonparametric
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
URI: http://discovery.ucl.ac.uk/id/eprint/1302015
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item