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Why the Schild method is better than Schild realised

Colquhoun, D; (2007) Why the Schild method is better than Schild realised. TRENDS PHARMACOL SCI , 28 (12) 608 - 614. 10.1016/j.tips.2007.09.011.

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Abstract

It is almost 60 years since Heinz Schild devised a method that allowed measurement of a genuine physical quantity, the equilibrium constant for binding of a competitive antagonist. The clever bit was that the measurements could be made using responses from tissues despite the fact that little or nothing was known about how the agonist worked. Since then, attempts have been made to generalise the Schild equation, but they are all based on false premises. It turns out that generalisation is usually not needed. His original simple result is still valid in cases where several agonist molecules must be bound to produce a response, even if the agonist binding sites interact or are not identical.

Type: Article
Title: Why the Schild method is better than Schild realised
DOI: 10.1016/j.tips.2007.09.011
Keywords: CHENG-PRUSOFF EQUATION, POWER EQUATIONS, SMOOTH MUSCLE, ACETYLCHOLINE, ANTAGONISM, RECEPTORS, SALTS, DRUGS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/130197
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