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The sulfonamide motif as a synthetic tool

Wilden, JD; (2010) The sulfonamide motif as a synthetic tool. J CHEM RES (10) 541 - 548. 10.3184/030823410X12857514635822.

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Sulfonamides are well known motifs in medicinal chemistry, forming a large family of antibacterial agents as well as being found in numerous other drugs. The chemistry of this functional group, however, is less well documented. This review seeks to bring together the various applications and advantages of this motif in organic synthesis, which includes the sulfonamide as an activating group, protecting group, leaving group and as a molecular scaffold.

Title:The sulfonamide motif as a synthetic tool
Keywords:sulfonamides, medicinal chemistry, reactivity, organic synthesis, VINYLSULFONAMIDES, REARRANGEMENT, REAGENTS, HALIDES, SULTAMS
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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