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How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia

Fielding, AK; (2010) How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia. BLOOD , 116 (18) 3409 - 3417. 10.1182/blood-2010-01-242750.

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Abstract

The Philadelphia chromosome is present in approximately 20% to 30% of adults with acute lymphoblastic leukemia (ALL). The poor prognosis of this relatively uncommon acute leukemia has led to the rapid adoption of treatment strategies such as unrelated donor hematopoietic stem cell transplant and tyrosine kinase inhibitors into clinical practice, despite a relative paucity of randomized clinical trials. Recently, there has been a surge of interest in the underlying biology of ALL. In combination with an accumulation of more mature clinical study data in Philadelphia-positive ALL, it is increasingly possible to make more rational and informed treatment choices for patients of all ages. In this article, I review available data and indicate how I personally interpret current evidence to make pragmatic treatment choices with my patients, outside of clinical trials. My strongest recommendation is that all physicians who are treating this rare disease actively seek appropriate clinical trials for their patients wherever possible. (Blood. 2010;116(18):3409-3417)

Type: Article
Title: How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia
DOI: 10.1182/blood-2010-01-242750
Keywords: STEM-CELL TRANSPLANTATION, BONE-MARROW-TRANSPLANTATION, IMATINIB-COMBINED CHEMOTHERAPY, ACUTE LYMPHOCYTIC-LEUKEMIA, CHRONIC MYELOID-LEUKEMIA, 1ST COMPLETE REMISSION, TERM-FOLLOW-UP, ADULT PATIENTS, PH PLUS, ALLOGENEIC TRANSPLANTATION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/1301402
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