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Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: A preliminary study

Harding, D; Brull, D; Humphries, SE; Whitelaw, A; Montgomery, H; Marlow, N; (2005) Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: A preliminary study. PEDIATR RES , 58 (1) 117 - 120. 10.1203/01.PDR.0000163523.49021.53.

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Abstract

The pro-inflammatory cytokine IL-6 may be neurocytopathogenic, and elevated levels are associated with impaired neurological outcome among children born prematurely. However, the precise mechanisms underlying this association remain unclear. The rare C (rather than G) variant at position -572 in the IL-6 gene is associated with an increased IL-6 synthetic response. If IL-6 mediates cerebral injury, we would anticipate the -572 C allele to be associated with impaired childhood development. We have examined this hypothesis, studying 113 Caucasian children born at <= 32 wk gestation. Cognitive and motor functions were assessed using the Griffiths Developmental Scales at 2 y and British Ability Scales (2nd Ed.) and the ABC Movement Score at 51/2 y. Performance (median, interquartile range) in all three scales was worse in the 10 carriers of the C allele than for those with GG genotype: Griffiths Developmental Quotient: C allele, 92.4 (89.9-96.6) versus CG 100.9 (96.7-104.8), p = 0.002; General Cognitive Ability: C allele, 88.0 (80.3-102.8) versus GG 103.0 (92.0-112.0), p = 0.037; Movement ABC score: C allele 8.3 (6.6-20.3) versus GG 4.0 (1.0-9.5), p = 0.081. The presence of the rare (>= 1) IL-6 -572 C-allele (CC+GC genotypes) is associated with impaired cognitive development among children born before 32 wk gestation. These data support a role for IL-6 in the genesis of neurologic impairment in such children.

Type: Article
Title: Variation in the interleukin-6 gene is associated with impaired cognitive development in children born prematurely: A preliminary study
DOI: 10.1203/01.PDR.0000163523.49021.53
Keywords: LOW-BIRTH-WEIGHT, WHITE-MATTER LESIONS, NECROSIS-FACTOR-ALPHA, BRAIN-DAMAGE, PRETERM INFANTS, PERIVENTRICULAR LEUKOMALACIA, INFLAMMATORY RESPONSE, PERINATAL ASPHYXIA, POLYMORPHISMS, PROMOTER
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Internal Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Neonatology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/130135
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