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Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner

Boswell, S; Sharif, S; Alisa, A; Pereira, SP; Williams, R; Behboudi, S; (2011) Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner. IMMUNOLOGY , 133 (3) 278 - 287. 10.1111/j.1365-2567.2011.03425.x.

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Abstract

P>CD4+ T cells expressing the latent form of transforming growth factor-beta [latency-associated peptide (LAP) (TGF-beta(1))] play an important role in the modulation of immune responses. Here, we identified a novel peptide ligand (GPC(81-95)) with an intrinsic ability to induce membrane-bound LAP (TGF-beta(1)) expression on a subpopulation of human CD4+ T cells (using flow cytometry; ranging from 0 center dot 8% to 2 center dot 6%) and stimulate peripheral blood mononuclear cells to release LAP (TGF-beta(1)) (using ELISPOT assay; ranging from 0 center dot 03% to 0 center dot 16%). In spite of this low percentage of responding cells, GPC(81-95) significantly reduced Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a TGF-beta(1)- and CD4+ T-cell-dependent manner. The results demonstrate that GPC(81-95) is a useful tool to study the functional properties of a subpopulation of LAP (TGF-beta(1))+ CD4+ T cells and suggest a pathway that can be exploited to suppress inflammatory response.

Type:Article
Title:Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner
DOI:10.1111/j.1365-2567.2011.03425.x
Keywords:CD4+T cells, glypican-3 derived peptide, latency-associated peptide (transforming growth factor-beta(1)), tumour necrosis factor-alpha, VASOACTIVE-INTESTINAL-PEPTIDE, ONCOFETAL PROTEIN GLYPICAN-3, REGULATORY T-CELLS, TGF-BETA, HEPATOCELLULAR-CARCINOMA, AUTOIMMUNE ENCEPHALOMYELITIS, CD3-SPECIFIC ANTIBODY, MARKER, TNF, CORTICOSTEROIDS

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