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F-18-FDG PET and biomarkers for tumour angiogenesis in early breast cancer

Groves, AM; Shastry, M; Rodriguez-Justo, M; Malhotra, A; Endozo, R; Davidson, T; ... Keshtgar, MR; + view all (2011) F-18-FDG PET and biomarkers for tumour angiogenesis in early breast cancer. EUR J NUCL MED MOL I , 38 (1) 46 - 52. 10.1007/s00259-010-1590-2.

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Abstract

Tumour angiogenesis is an independent and strong prognostic factor in early breast carcinoma. We performed this study to investigate the ability of F-18-FDG to detect angiogenesis in early breast carcinoma using PET/CT.Twenty consecutive patients with early (T1-T2) breast carcinoma were recruited prospectively for 18F-FDG PET/CT. The PET/CT data were used to calculate whole tumour maximum standardized uptake value (SUVmax) and mean standardized uptake value (SUVmean). All patients underwent subsequent surgery without prior chemotherapy or radiotherapy. The excised tumour underwent immunohistochemistry for vascular endothelial growth factor (VEGF), CD105 and glucose transporter protein 1 (GLUT1).The SUVmax showed the following correlation with tumour histology: CD105: r = 0.60, p = 0.005; GLUT1: r = 0.21, p = 0.373; VEGF: r = -0.16, p = 0.496. The SUVmean showed the following correlation with tumour histology: CD105: r = 0.65, p = 0.002; GLUT1: r = 0.34, p = 0.144; VEGF: r = -0.18, p = 0.443F-18-FDG uptake is highly significantly associated with angiogenesis as measured by the immunohistochemistry with CD105 for new vessel formation. Given that tumour angiogenesis is an important prognostic indicator and a predictor of treatment response, F-18-FDG PET may have a role in the management of primary breast cancer patients even in early-stage disease.

Type:Article
Title:F-18-FDG PET and biomarkers for tumour angiogenesis in early breast cancer
DOI:10.1007/s00259-010-1590-2
Keywords:Angiogenesis, Breast cancer, Positron emission tomography, CELL LUNG-CANCER, POSITRON-EMISSION-TOMOGRAPHY, CD105 EXPRESSION, GROWTH-FACTOR, PROGNOSTIC-SIGNIFICANCE, MICROVESSEL DENSITY, CLINICAL-TRIALS, ENDOGLIN CD105, CARCINOMAS, ANTIBODY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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