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Detection of the sentinel lymph node in breast cancer

Somasundaram, SK; Chicken, DW; Keshtgar, MRS; (2007) Detection of the sentinel lymph node in breast cancer. BRIT MED BULL , 84 117 - 131. 10.1093/bmb/ldm032.

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Abstract

Introduction: Introduction: Axillary lymph node status for lymphatic staging in breast cancer is the best prognostic indicator and guides systemic treatment. Sentinel lymph node (SLN) biopsy is a novel, minimally invasive technique for lymphatic staging proven to improve quality of life. The accurate detection of the SLN is paramount for the success of the procedure.Methods: Relevant literature was reviewed with regards to the different dyes and techniques used for the detection of SLN in breast cancer.Results: Highest identification rates and lowest false negative rates are achieved by using the combined blue dye and radiocolloid technique with pre-operative imaging using a gamma camera. There is a well-recognized learning curve to successfully perform SLN biopsy.Conclusions: The concept of SLN has been well validated and is the standard of care in early breast cancer. A multidisciplinary approach and structured training is the key to the successful introduction of the technique.

Type: Article
Title: Detection of the sentinel lymph node in breast cancer
DOI: 10.1093/bmb/ldm032
Keywords: sentinel lymph node, breast cancer, sentinel node imaging, NEW START, STANDARD AXILLARY TREATMENT, BIOPSY, DISSECTION, VALIDATION, CARCINOMA, TRIAL, METAANALYSIS, METASTASES, INJECTION, NOMOGRAM
UCL classification: UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/1301169
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