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THE ASSOCIATION BETWEEN TYPHOID CARRIAGE, TYPHOID INFECTION AND SUBSEQUENT CANCER AT A NUMBER OF SITES

CAYGILL, CPJ; BRADDICK, M; HILL, MJ; KNOWLES, RL; SHARP, JCM; (1995) THE ASSOCIATION BETWEEN TYPHOID CARRIAGE, TYPHOID INFECTION AND SUBSEQUENT CANCER AT A NUMBER OF SITES. EUR J CANCER PREV , 4 (2) 187 - 193.

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Abstract

It has been demonstrated that bacteria can produce the very potent carcinogens (N-nitroso compounds), from nitrite and suitable amines, It has been hypothesized that this can happen whenever a body site which is normally sterile becomes colonized by bacteria, If this is so then such chronic infections should result in an increased incidence of local cancers and also of cancers at some distant sites, To test this we studied the risk of cancer at various sites in a cohort of chronic carriers of Salmonella typhi/paratyphi. We have observed a greatly increased risk of cancers of the biliary tract and also of cancers of the colorectum, pancreas, lung and all sites, The results are discussed in terms of the hypothesis being tested.

Type:Article
Title:THE ASSOCIATION BETWEEN TYPHOID CARRIAGE, TYPHOID INFECTION AND SUBSEQUENT CANCER AT A NUMBER OF SITES
Keywords:BILIARY TRACT CANCER, CANCER RISK, CHRONIC CARRIERS, PRECURSOR STATES, TYPHOID CARRIAGE, GASTRIC-SURGERY, PEPTIC-ULCER, CHOLECYSTECTOMY, EPIDEMIOLOGY, NITROSAMINE, CARCINOMA
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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