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Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene

Panahloo, A; Mohammad-Ali, V; Gray, RP; Humphries, SE; Yudkin, JS; (2003) Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene. ATHEROSCLEROSIS , 168 (2) 297 - 304. 10.1016/S0021-9150(03)00095-9.

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Abstract

High PAI-1 levels post acute myocardial infarction (AMI) are associated with a poor outcome. Concentrations of insulin-like molecules, proinflammatory cytokines and an insertion (5G)/deletion (4G) polymorphism in the promoter of the PAI-1 gene, all influence circulating PAI-1 levels. We studied the determinants of PAI-1 in 123 patients immediately following and at 6 months after AMI. Within 24 h of AMI, PAI-1 levels were related to those of proinsulin-like molecules but not to levels of cytokines (interleukin-1beta, interleukin-6 or tumour necrosis factor-alpha), to genotype, or to interactions between genotype and cytokine concentration. PAI-1 levels 6 months after AMI were related to concentrations of interleukin-1beta but not to genotype. We have found no evidence that subjects with the 4G/4G polymorphism have higher PAI-1 levels on admission or 6 months after AMI. In these patients, levels of PAI-1 are related to concentrations of proinsulin-like molecules and of proinflammatory cytokines. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

Type:Article
Title:Plasminogen activator inhibitor-1 (PAI-1) activity post myocardial infarction: the role of acute phase reactants, insulin-like molecules and promoter (4G/5G) polymorphism in the PAI-1 gene
DOI:10.1016/S0021-9150(03)00095-9
Keywords:plasminogen activator inhibitor-1 (PAI-1), PAI-1 gene, proinsulin-like molecules, myocardial infarction, cytokines, NECROSIS-FACTOR-ALPHA, C-REACTIVE PROTEIN, CARDIOVASCULAR RISK-FACTORS, CORONARY-ARTERY-DISEASE, CELLS-IN-VITRO, ENDOTHELIAL-CELLS, DIABETIC-PATIENTS, PLASMA-INSULIN, TYPE-1 PAI-1, CIRCADIAN FLUCTUATIONS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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