Bentley, DR and Deloukas, P and Dunham, A and French, L and Gregory, SG and Humphray, SJ and Mungall, AJ and Ross, MT and Carter, NP and Dunham, I and Scott, CE and Ashcroft, KJ and Atkinson, AL and Aubin, K and Beare, DM and Bethel, G and Brady, N and Brook, JC and Burford, DC and Burrill, WD and Burrows, C and Butler, AP and Carder, C and Catanese, JJ and Clee, CM and Clegg, SM and Cobley, V and Coffey, AJ and Cole, CG and Collins, JE and Conquer, JS and Cooper, RA and Culley, KM and Dawson, E and Dearden, FL and Durbin, RM and de Jong, PJ and Dhami, PD and Earthrowl, ME and Edwards, CA and Evans, RS and Gillson, CJ and Ghori, J and Green, L and Gwilliam, R and Halls, KS and Hammond, S and Harper, GL and Heathcott, RW and Holden, JL and Holloway, E and Hopkins, BL and Howard, PJ and Howell, GR and Huckle, EJ and Hughes, J and Hunt, PJ and Hunt, SE and Izmajlowicz, M and Jones, CA and Joseph, SS and Laird, G and Langford, CF and Lehvaslaiho, MH and Leversha, MA and McCann, OT and McDonald, LM and McDowall, J and Maslen, GL and Mistry, D and Moschonas, NK and Neocleous, V and Pearson, DM and Phillips, KJ and Porter, KM and Prathalingam, SR and Ramsey, YH and Ranby, SA and Rice, CM and Rogers, J and Rogers, LJ and Sarafidou, T and Scott, DJ and Sharp, GJ and Shaw-Smith, CJ and Smink, LJ and Soderlund, C and Sotheran, EC and Steingruber, HE and Sulston, JE and Taylor, A and Taylor, RG and Thorpe, AA and Tinsley, E and Warry, GL and Whittaker, A and Whittaker, P and Williams, SH and Wilmer, TE and Wooster, R and Wright, CL (2001) The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X. NATURE , 409 (6822) 942 - 943.
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Abstract
We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.
| Type: | Article |
|---|---|
| Title: | The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X |
| Keywords: | HUMAN GENOME |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science |
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