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The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X

Bentley, DR; Deloukas, P; Dunham, A; French, L; Gregory, SG; Humphray, SJ; ... Wright, CL; + view all (2001) The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X. NATURE , 409 (6822) 942 - 943.

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Abstract

We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.

Type:Article
Title:The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X
Keywords:HUMAN GENOME
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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