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Nanoparticles: their potential use in antibacterial photodynamic therapy

Perni, S; Prokopovich, P; Pratten, J; Parkin, IP; Wilson, M; (2011) Nanoparticles: their potential use in antibacterial photodynamic therapy. PHOTOCH PHOTOBIO SCI , 10 (5) 712 - 720. 10.1039/c0pp00360c.

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Abstract

Photodynamic therapy (PDT) has been proposed as a new technique to inactivate microorganisms as it does not lead to the selection of mutant resistant strains; a clear benefit compared to antibiotic treatment. PDT has also attracted the interest of nanotechnology as the effectiveness of the treatment can be greatly enhanced by the use of nanoparticles. In the last decade, different approaches to the combination of nanoparticles and PDT have been investigated in relation to the antimicrobial applications of the technique. One use of the nanoparticles is to improve the delivery of photosensitiser to the bacteria; others use the nanoparticles to improve the inactivation kinetics. A different approach utilises nanoparticles as a photosensitiser. In this review these diverse types of interactions will be described.

Type:Article
Title:Nanoparticles: their potential use in antibacterial photodynamic therapy
DOI:10.1039/c0pp00360c
Keywords:RESISTANT STAPHYLOCOCCUS-AUREUS, KERATINOCYTES IN-VITRO, GRAM-POSITIVE BACTERIA, METHYLENE-BLUE, ESCHERICHIA-COLI, SINGLET-OXYGEN, TOLUIDINE BLUE, LETHAL PHOTOSENSITIZATION, GOLD NANOPARTICLES, FULLERENE C-60
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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