Boshoff, C (2011) Unraveling virus-induced lymphomagenesis. J CLIN INVEST , 121 (3) 838 - 841. 10.1172/JCI46499.
Abstract
Kaposi sarcoma herpesvirus (KSHV), a human gammaherpesvirus, is the etiological agent for the endothelial-derived Kaposi sarcoma (KS) and also for certain lymphoproliferative disorders. In these lymphoproliferations, the KSHV-infected cells carry the stigmata of B lymphocytes, with plasmablastic features. The JCI has published three manuscripts addressing key questions related to B cell infection and viral latent expression in B cells. Myoung and Ganem provide evidence that CD4(+) lymphocytes suppress KSHV replication, promoting latency in B cells; Hassman and colleagues show that KSHV infection drives plasmablast differentiation in a subset of IgM(+) lambda light chain-expressing cells; and Ballon and colleagues describe the in vivo transdifferentiation of B lymphocytes by KSHV-encoded viral FLICE-inhibitory protein (vFLIP).
| Type: | Article |
|---|---|
| Title: | Unraveling virus-induced lymphomagenesis |
| Open access status: | An open access publication |
| DOI: | 10.1172/JCI46499 |
| Publisher version: | http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3046640/?tool=pubmed |
| Keywords: | EPSTEIN-BARR-VIRUS, MULTICENTRIC CASTLEMANS-DISEASE, KAPPA-B, KAPOSIS-SARCOMA, PROTEIN EXPRESSION, DNA-SEQUENCES, HUMAN-HERPESVIRUS-8, CELLS, INFECTION, LYMPHOCYTES |
| UCL classification: | UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Cancer Biology |
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