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The ACE I/D polymorphism and human physical performance

Woods, DR; Humphries, SE; Montgomery, HE; (2000) The ACE I/D polymorphism and human physical performance. TRENDS ENDOCRIN MET , 11 (10) 416 - 420.

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Abstract

The D allele of the angiotensin-converting enzyme (ACE) I/D polymorphism is associated with elevated levels of serum and tissue ACE, increased production of the vasopressor angiotensin II and a reduction in the half-life of the vasodilator bradykinin. Several cardiac and venal conditions appear to have a worse prognosis in subjects homozygous for the D allele, whereas the I allele has been associated with enhanced endurance performance in elite distance runners, rowers avid mountaineers. The nature of the gene-environment interaction between ACE I/D polymorphisms and physical training, an overview of recent findings and a discussion of possible underlying mechanisms is the subject of this review.

Type:Article
Title:The ACE I/D polymorphism and human physical performance
Keywords:ANGIOTENSIN-CONVERTING-ENZYME, CONGESTIVE-HEART-FAILURE, MAXIMUM OXYGEN-UPTAKE, SKELETAL-MUSCLE, ENDURANCE PERFORMANCE, MUSCULAR EFFICIENCY, HERITAGE FAMILY, ID POLYMORPHISM, GENE, BRADYKININ
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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