Dickinson, KJ; Cockbain, AJ; MacDonald, W; Shah, M; Homer-Vanniasinkam, S; (2009) The Physiological Effects of Short-term Smoking Cessation in Claudicants. ANGIOLOGY , 60 (2) 159 - 163. 10.1177/0003319708325448.
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Introduction: Smoking contributes to atherosclerosis and causes significant postoperative morbidity. New antismoking law forces short-term pre-operative abstinence. Demonstrable clinical benefit might motivate complete cessation. Our aim was to determine the effects of 24-hr smoking cessation on cardiorespiratory function and claudication distance. Methods: Smoking claudicants were randomized to 24hr smoking or abstinence. Following these separate periods, cardiopulmonary exercise testing was performed. Pre- and post-exercise, serum lactate and ankle brachial pressure index (ABPI) were measured. During exercise, cardiorespiratory function, initial and absolute claudication (IC,AC) distances and visual analogue scores (VAS) of pain were recorded. Results: 16 patients completed both tests. IC, AC and VAS were unchanged with abstinence (P = .43, .66, .96, .83). ABPI drop post-exercise was unchanged with abstinence (P = .08, .09). Cardiorespiratory function was not affected by smoking cessation. Conclusion: Cardiorespiratory function and claudication symptoms are unchanged following 24-hr smoking cessation., No deterioration in respiratory function is important when considering anaesthetic administration. However, lack of symptomatic improvement may discourage patients from abstaining. Further investigation should determine correlation between short-term abstinence and postoperative morbidity.
|Title:||The Physiological Effects of Short-term Smoking Cessation in Claudicants|
|Keywords:||Smoking, atherosclerosis, peripheral arterial disease, ARTERY BYPASS PATIENTS, CIGARETTE-SMOKING, INTERMITTENT CLAUDICATION, PULMONARY COMPLICATIONS, PREOPERATIVE CESSATION, CARBON-MONOXIDE, EXERCISE, ABSTINENCE, DISEASE, SMOKERS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
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