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The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease

Dunn, S; Vohra, RS; Murphy, JE; Homer-Vanniasinkam, S; Walker, JH; Ponnambalam, S; (2008) The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease. BIOCHEM J , 409 349 - 355. 10.1042/BJ20071196.

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Abstract

Scavenger receptors are membrane glycoproteins that bind diverse ligands including lipid particles, phospholipids, apoptotic cells and pathogens. LOX-1 (lectin-like oxidized low-density lipoprotein receptor-1) is increasingly linked to atherosclerotic plaque formation. Transgenic mouse models for LOX-1 overexpression or gene knockout suggests that LOX-1 contributes to atherosclerotic plaque formation and progression. LOX1 activation by oxidized LDL (low-density lipoprotein) binding stimulates intracellular signalling, gene expression and production of superoxide radicals. A key question is the role of leucocyte LOX-1 in pro-atherogenic lipid particle trafficking, accumulation and signalling leading to differentiation into foam cells, necrosis and plaque development. LOX-1 expression is elevated within vascular lesions and a serum soluble LOX1 fragment appears diagnostic of patients with acute coronary syndromes. LOX-1 is increasingly viewed as a vascular disease biomarker and a potential therapeutic target in heart attack and stroke prevention.

Type:Article
Title:The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease
DOI:10.1042/BJ20071196
Keywords:apoptosis, atherosclerosis, lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), oxidized low-density lipoprotein (OxLDL), scavenger receptor, ARTERY ENDOTHELIAL-CELLS, NF-KAPPA-B, ACUTE MYOCARDIAL-INFARCTION, UP-REGULATES LOX-1, OX-LDL RECEPTOR-1, SCAVENGER RECEPTOR, LIGAND-BINDING, ATHEROSCLEROTIC LESIONS, MONOCYTE RECRUITMENT, SURFACE EXPRESSION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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