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Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation

Gomez, D; Homer-Vanniasinkam, S; Graham, AM; Prasad, KR; (2007) Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation. WORLD J GASTROENTERO , 13 (5) 657 - 670. Gold open access

Abstract

Liver ischaemic preconditioning (IPC) is known to protect the liver from the detrimental effects of ischaemic-reperfusion injury (IRI), which contributes significantly to the morbidity and mortality following major liver surgery. Recent studies have focused on the role of IPC in liver regeneration, the precise mechanism of which are not completely understood. This review discusses the current understanding of the mechanism of liver regeneration and the role of IPC in this setting. Relevant articles were reviewed from the published literature using the Medline database. The search was performed using the keywords "liver", "ischaemic reperfusion" ' "ischaemic preconditioning", "regeneration". "hepatectomy" and "transplantation". The underlying mechanism of liver regeneration is a complex process involving the interaction of cytokines, growth factors and the metabolic demand of the liver. IPC, through various mediators, promotes liver regeneration by up-regulating growthpromoting factors and suppresses growth-inhibiting factors as well as damaging stresses. The increased understanding of the cellular mechanisms involved in IPC will enable the development of alternative treatment modalities aimed at promoting liver regeneration following major liver resection and transplantation. (c) 2007 The WJG Press. All rights reserved.

Type:Article
Title:Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation
Open access status:An open access publication
Publisher version:http://www.wjgnet.com/1007-9327/index.htm
Keywords:liver regeneration, ischaemic reperfusion, ischaemic preconditioning, hepatectomy, transplantation, HEPATOCYTE GROWTH-FACTOR, NF-KAPPA-B, TUMOR-NECROSIS-FACTOR, CELL-CYCLE PROGRESSION, ADULT-RAT HEPATOCYTES, REDUCED-SIZE LIVER, HEPATIC COLORECTAL METASTASES, SINUSOIDAL ENDOTHELIAL-CELLS, SIGNAL-TRANSDUCTION PATHWAY, ORGANIC ANION TRANSPORTERS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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