Ischaemic preconditioning protects against ischaemia/reperfusion injury: Emerging concepts.
EUR J VASC ENDOVASC
106 - 115.
Introduction. Ischaemic preconditioning (IP) has emerged as a powerful method of ameliorating ischaemia/reperfusion (I/R) injury to the myocardium. This review investigates whether this phenomenon is universally applicable in modulating I/R injury to other tissues.Methods. A Medline search was conducted to identify both animal and human studies that described IP-induced protection from I/R injury in a variety of non-cardiac organ systems. Particular emphasis was placed on elucidation of underlying physiological concepts.Results and conclusions. IP utilises endogenous mechanisms in skeletal muscle, liver, lung, kidney, intestine and brain in animal models to convey varying degrees of protection from I/R injury. To date there are few human studies, but recent reports suggest that human liver, lung and skeletal muscle acquire similar protection after IP. Specifically, preconditioned tissues exhibit reduced energy requirements, altered energy metabolism, better electrolyte homeostasis and genetic reorganisation, giving rise to the concept of 'ischaemia tolerance. IP also induces 'reperfusion tolerance' with less reactive oxygen species and activated neutrophils released, reduced apoptosis and better microcirculatory perfusion compared to nonpreconditioned tissue. Systemic I/R injury is also diminished by preconditioning. IP is ubiquitous but more research is required to fully translate these findings to the clinical arena.
|Title:||Ischaemic preconditioning protects against ischaemia/reperfusion injury: Emerging concepts|
|Keywords:||ischaemic preconditioning, reperfusion injury, myocardium, skeletal muscle, liver, lung, intestine, brain, kidney, ISOLATED RAT HEPATOCYTES, REPERFUSION INJURY, SKELETAL-MUSCLE, PERMEABILITY TRANSITION, NITRIC-OXIDE, ISCHEMIA/REPERFUSION-INJURY, ADENOSINE-MONOPHOSPHATE, CELLULAR ENERGETICS, ADHESION MOLECULES, ENERGY-METABOLISM|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)|
Archive Staff Only