UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Primary intra-osseous liposarcoma of the femur: a case report.

Macmull, S; Atkinson, HD; Saso, S; Tirabosco, R; O'Donnell, P; Skinner, JA; (2009) Primary intra-osseous liposarcoma of the femur: a case report. J Orthop Surg (Hong Kong) , 17 (3) pp. 374-378. Gold open access

Abstract

We report a rare case of an intra-osseous liposarcoma of the proximal femur. A 26-year-old man presented with a 6-month history of left groin pain radiating to the knee and an antalgic gait. Radiology showed a predominantly fatty lesion in the medial aspect of the femoral neck extending toward the lesser trochanter; most of the marrow in the femoral neck had been replaced without evidence of an extra-osseous mass; and the posterior cortex had been destroyed. Histological and immunohistochemical analyses of the tumour after open biopsy were indicative of high-grade liposarcomatous malignancy. After exclusion of any other primary tumour foci or metastases on regional and whole-body magnetic resonance images, the diagnosis of a high-grade intra-osseous primary liposarcoma of the proximal femur was made. The patient received 2 preoperative courses of neoadjuvant doxorubicin, cisplatin and methotrexate. After proximal femoral replacement following en bloc excision of the proximal femur, 4 more cycles of adjuvant ifosfamide and etoposide were given. At the 16-month follow-up, he remained independently ambulatory, with no local or distant recurrence. Tissue diagnosis and multimodal imaging, rather than any single radiological investigation, are important in making the diagnosis.

Type: Article
Title: Primary intra-osseous liposarcoma of the femur: a case report.
Location: England
Open access status: An open access publication
Keywords: Adult, Antineoplastic Combined Chemotherapy Protocols, Biopsy, Cisplatin, Combined Modality Therapy, Diagnosis, Differential, Doxorubicin, Etoposide, Femoral Neoplasms, Humans, Ifosfamide, Liposarcoma, Magnetic Resonance Imaging, Male, Methotrexate, Neoadjuvant Therapy, Radiography, Whole Body Imaging
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1299243
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item