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Primary intra-osseous liposarcoma of the femur: a case report.

Macmull, S; Atkinson, HDE; Saso, S; Tirabosco, R; O'Donnell, P; Skinner, JA; (2009) Primary intra-osseous liposarcoma of the femur: a case report. J Orthop Surg (Hong Kong) , 17 (3) pp. 374-378. 10.1177/230949900901700327. Gold open access


We report a rare case of an intra-osseous liposarcoma of the proximal femur. A 26-year-old man presented with a 6-month history of left groin pain radiating to the knee and an antalgic gait. Radiology showed a predominantly fatty lesion in the medial aspect of the femoral neck extending toward the lesser trochanter; most of the marrow in the femoral neck had been replaced without evidence of an extra-osseous mass; and the posterior cortex had been destroyed. Histological and immunohistochemical analyses of the tumour after open biopsy were indicative of high-grade liposarcomatous malignancy. After exclusion of any other primary tumour foci or metastases on regional and whole-body magnetic resonance images, the diagnosis of a high-grade intra-osseous primary liposarcoma of the proximal femur was made. The patient received 2 preoperative courses of neoadjuvant doxorubicin, cisplatin and methotrexate. After proximal femoral replacement following en bloc excision of the proximal femur, 4 more cycles of adjuvant ifosfamide and etoposide were given. At the 16-month follow-up, he remained independently ambulatory, with no local or distant recurrence. Tissue diagnosis and multimodal imaging, rather than any single radiological investigation, are important in making the diagnosis.

Type: Article
Title: Primary intra-osseous liposarcoma of the femur: a case report.
Location: England
Open access status: An open access publication
DOI: 10.1177/230949900901700327
Keywords: Adult, Antineoplastic Combined Chemotherapy Protocols, Biopsy, Cisplatin, Combined Modality Therapy, Diagnosis, Differential, Doxorubicin, Etoposide, Femoral Neoplasms, Humans, Ifosfamide, Liposarcoma, Magnetic Resonance Imaging, Male, Methotrexate, Neoadjuvant Therapy, Radiography, Whole Body Imaging
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/1299243
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