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Sib-pair linkage analysis of longitudinal changes in lipoprotein risk factors and lipase genes in women twins

Friedlander, Y; Talmud, PJ; Edwards, KL; Humphries, SE; Austin, MA; (2000) Sib-pair linkage analysis of longitudinal changes in lipoprotein risk factors and lipase genes in women twins. J LIPID RES , 41 (8) 1302 - 1309. Gold open access

Abstract

Based on longitudinal twin data in women, we have previously demonstrated a genetic influence on changes in lipoprotein risk factors, blood pressure measurements, and body mass index over a decade. The present study examined the linkage between changes in lipoprotein variables and candidate genes encoding the hormone-sensitive lipase (HSL), hepatic lipase (HL), and lipoprotein lipase (LPL), The sample consisted of 126 dizygotic (DZ) pairs of women twins who participated in the two examinations of the Kaiser Permanente Women Twins Study, performed a decade apart. Using quantitative sib-pair linkage analysis, a linkage was demonstrated between the locus for hormone-sensitive lipase and age-adjusted changes in plasma triglyceride (P = 0,015), which became more significant after adjustment for environmental factors and the exam-1 level (P = 0,005), There was also evidence suggesting linkage between the locus for hepatic lipase and changes in triglyceride (P = 0,023), but no linkage was detected for lipoprotein lipase and changes of lipid levels with time.jlr These findings suggest that variation at these candidate gene loci may underlie a portion of the intraindividual variations in these corollary heart disease (CHD) risk factors, and that studies to identify the functional variants could provide new insights into genetic susceptibility to cardiovascular disease.

Type:Article
Title:Sib-pair linkage analysis of longitudinal changes in lipoprotein risk factors and lipase genes in women twins
Open access status:An open access publication
Publisher version:http://www.jlr.org/papbyrecent.shtml
Keywords:lipoprotein lipase, hepatic lipase, hormone-sensitive lipase, candidate genes, lipids, lipoproteins, twins, linkage, sib-pair, HORMONE-SENSITIVE LIPASE, FAMILIAL COMBINED HYPERLIPIDEMIA, CORONARY-ARTERY DISEASE, EUROPEAN ATHEROSCLEROSIS RESEARCH, INSULIN-RESISTANCE SYNDROME, HIGH-DENSITY-LIPOPROTEIN, BODY-MASS INDEX, HEPATIC LIPASE, HDL CHOLESTEROL, HEART-DISEASE
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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