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Immune Responses in Patients With Metal-on-Metal Hip Articulations

Whittingham-Jones, PM; Dunstan, E; Altaf, H; Cannon, SR; Revell, PA; Briggs, TWR; (2008) Immune Responses in Patients With Metal-on-Metal Hip Articulations. J ARTHROPLASTY , 23 (8) 1212 - 1218. 10.1016/j.arth.2007.10.015.

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Abstract

Metal-on-metal (MoM) hip bearings are being inserted into ever-younger patients. The effects on the immune system of chronic exposure are unknown. We investigated the immune response of patients with MoM hip bearings. In patients with MoM implants, the expression of antigen-presenting cell (APC) surface molecules (CD86 and HLA-DR) was seen to be significantly higher (P < .05) than control group. High levels of APC surface molecules suggest an activated state and attempts to propagate an immune response. However, in the same group, the expression of T-cell markers (CD3 and CD28) was low, indicating a small T-cell population. This suggests, despite the activation of APCs, that T cells down-regulate immune responses in MoM articulations. Conversely, in metal-on-polyethylene articulations, expression of T-cell molecules was elevated and expression of APC molecules lowered.

Type:Article
Title:Immune Responses in Patients With Metal-on-Metal Hip Articulations
DOI:10.1016/j.arth.2007.10.015
Keywords:immune responses, metal-on-metal, hip, metal-on-polyethylene, T-CELLS, ACETABULAR COMPONENTS, ORTHOPEDIC IMPLANTS, IN-VIVO, COSTIMULATION, ARTHROPLASTY, WEAR, CD86, REPLACEMENTS, APOPTOSIS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of) > Institute of Orthopaedics and Musculoskeletal Science

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