UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Folate, vitamin B-12 and postmenopausal breast cancer in a prospective study of French women

Lajous, M; Romieu, I; Sabia, S; Boutron-Ruault, MC; Clavel-Chapelon, F; (2006) Folate, vitamin B-12 and postmenopausal breast cancer in a prospective study of French women. CANCER CAUSE CONTROL , 17 (9) 1209 - 1213. 10.1007/s10552-006-0053-3.

Full text not available from this repository.

Abstract

Objective Adequate folate intake may be important for breast cancer prevention. Its protective effect may be influenced by factors associated with folate metabolism. We sought to evaluate folate intake in relation to breast cancer risk and examine whether the relation is affected by alcohol and intake of vitamin B-2 and B-12.Methods A prospective cohort analysis of folate intake was conducted among 62,739 postmenopausal women in the French E3N cohort who had completed a validated food frequency questionnaire in 1993. During nine years' follow-up, 1,812 cases of pathology-confirmed breast cancer were documented through follow-up questionnaires. Nutrients were categorized in quintiles and energy-adjusted using the regression-residual method. Cox model-derived relative risks (RRs) were adjusted for known breast cancer determinants.Results The multivariate RR for extreme quintiles of folate intake was 0.78 (95% CI: 0.67-0.90; p-trend = 0.001) [Median intake for Q(1) = 296 mu g/day and Q(5) = 522 mu g/day]. There was no evidence to support effect modification by alcohol or B-2 intake. The decreasing trend was most marked in women with higher folate and vitamin B-12 intake. However, test for interaction was not statistically significant (p = 0.29).Conclusions High folate intake was associated with decreased breast cancer risk. Vitamin B-12 intake may modify this association.

Type: Article
Title: Folate, vitamin B-12 and postmenopausal breast cancer in a prospective study of French women
DOI: 10.1007/s10552-006-0053-3
Keywords: breast cancer, women, nutrition, folate, vitamin B-12, vitamin B-2, alcohol, diet, DNA METHYLATION, BETA-CAROTENE, RISK, HYPOMETHYLATION, CARCINOGENESIS, METHIONINE, ALCOHOL, COHORT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
URI: http://discovery.ucl.ac.uk/id/eprint/1298923
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item