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Genetics of Dilated Cardiomyopathy: Risk of Conduction Defects and Sudden Cardiac Death.

Arnous, S; Syrris, P; Sen-Chowdhry, S; McKenna, WJ; (2010) Genetics of Dilated Cardiomyopathy: Risk of Conduction Defects and Sudden Cardiac Death. Card Electrophysiol Clin , 2 (4) pp. 599-609. 10.1016/j.ccep.2010.09.008.

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Abstract

Dilated cardiomyopathy is familial in at least 40--60% of cases and causal mutations have been identified in more than 40 different genes. Mutations in lamin A/C (LMNA) and desmosomal components appear associated with increased risk of sudden cardiac death, the latter in the context of left-dominant arrhythmogenic cardiomyopathy. Specific clinical features may be valuable in identifying patients with these mutations. Routine sequencing of all the genes implicated in dilated cardiomyopathy may not be cost-effective at present. Targeted mutation screening of LMNA and desmosomal components is recommended and may facilitate prognostication and management.

Type: Article
Title: Genetics of Dilated Cardiomyopathy: Risk of Conduction Defects and Sudden Cardiac Death.
Location: United States
DOI: 10.1016/j.ccep.2010.09.008
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
URI: http://discovery.ucl.ac.uk/id/eprint/1298633
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