Arnous, S; McKenna, WJ; Syrris, P; Sen-Chowdhry, S; (2010) Genetics of dilated cardiomyopathy: Risk of conduction defects and sudden cardiac death. Cardiac Electrophysiology Clinics , 2 (4) 599 - 609. 10.1016/j.ccep.2010.09.008.
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Dilated cardiomyopathy is familial in at least 40--60% of cases and causal mutations have been identified in more than 40 different genes. Mutations in lamin A/C (LMNA) and desmosomal components appear associated with increased risk of sudden cardiac death, the latter in the context of left-dominant arrhythmogenic cardiomyopathy. Specific clinical features may be valuable in identifying patients with these mutations. Routine sequencing of all the genes implicated in dilated cardiomyopathy may not be cost-effective at present. Targeted mutation screening of LMNA and desmosomal components is recommended and may facilitate prognostication and management. © 2010.
|Title:||Genetics of dilated cardiomyopathy: Risk of conduction defects and sudden cardiac death|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science|
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