Acute pancreatitis is an inflammatory condition with a variable clinical course. Diagnosis is based upon clinical presentation, laboratory indices and imaging studies, whilst illness severity can be assessed by clinical scoring systems, such as the Ranson, Glasgow or APACHE II criteria, or by radiological assessments such as the CT severity index. Most patients develop self-limiting disease. However, a minority progress to a severe form with both local and systemic complications. Management is usually non-operative with interventional therapy reserved for those with common bile duct stones or complications such as pancreatic abscess and pseudocyst formation. This article will review the pathophysiology, assessment and treatment of acute pancreatitis, the evidence for nutritional support and the use of antibiotics, and the indications for and timing of interventional therapy. © 2010 Elsevier Ltd. All rights reserved.
|Keywords:||acute, antibiotics, complications, management, nutrition, pancreatitis, severity|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)
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