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Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides

Ross, SJM; Brewin, CR; Curran, HV; Furlong, CE; Abraham-Smith, KM; Harrison, V; (2010) Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides. NEUROTOXICOL TERATOL , 32 (4) 452 - 459. 10.1016/j.ntt.2010.03.004.

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Abstract

The study aim was to determine whether low level exposure to organophosphate pesticides (OPs) causes neuropsychological or psychiatric impairment. Methodological weaknesses of earlier studies were addressed by: recruiting participants who had retired on ill health grounds; excluding participants with a history of acute poisoning, medical or psychiatric conditions that might account for ill health; and exploring factors which may render some individuals more vulnerable to the effects of OPs than others. Performance on tests of cognition and mood of 127 exposed sheep farmers (67 working, 60 retired) was compared with 78 unexposed controls (38 working, 40 retired) and published test norms derived from a cross section of several thousand adults in the general population. Over 40% of the exposed cohort reported clinically significant levels of anxiety and depression compared to less than 23% of controls. Exposed subjects performed significantly worse than controls and standardisation samples on tests of memory, response speed, fine motor control, mental flexibility and strategy making, even after controlling for the effects of mood. The pattern was similar for both working and retired groups. The cognitive deficits identified cannot be attributed to mood disorder, malingering, a history of acute exposure or genetic vulnerability in terms of PON1(192) polymorphisms. Results suggest a relationship may exist between low level exposure to organophosphates and impaired neurobehavioural functioning and these findings have implications for working practice and for other occupational groups exposed to OPs such as aviation workers and Gulf War veterans. (C) 2010 Elsevier Inc. All rights reserved.

Type: Article
Title: Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides
DOI: 10.1016/j.ntt.2010.03.004
Keywords: Organophosphates, Neurobehavioural, Neuropsychological, Cognitive dysfunction, Farm workers, LONG-TERM EXPOSURE, DIPPING SHEEP, PON1 STATUS, ILL-HEALTH, PARAOXONASE, WORKERS, DIP, ABNORMALITIES, POLYMORPHISMS, APPLICATORS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/129818
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