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Aspirin particle formation by electric-field-assisted release of droplets

Li, SW; Jayasinghe, SN; Edirisinghe, MJ; (2006) Aspirin particle formation by electric-field-assisted release of droplets. CHEM ENG SCI , 61 (10) 3091 - 3097. 10.1016/j.ces.2005.08.004.

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Abstract

An aspirin solution flowing through a needle at 0.36ml h(-1) (10(-10) m(3) s(-1)) was subjected to an electric field of 0.36kV mm(-1) to generate droplets. The aspirin droplet size distribution generated was measured and is shown to be trimodal with the most significant size, similar to 6 mu m. Deposited droplets and their aspirin crystal relics were also studied by electron microscopy. Immediately after deposition, the droplets were remarkably uniform in size and produced particulate crystals << 10 mu m and were considerably more regular in morphology when compared with those formed without using an electric field. (c) 2005 Elsevier Ltd. All rights reserved.

Type:Article
Title:Aspirin particle formation by electric-field-assisted release of droplets
DOI:10.1016/j.ces.2005.08.004
Keywords:electric-field, biomedicine, aspirin particulates, droplets, CONE-JET MODE, DRY POWDER INHALERS, ELECTROSTATIC ATOMIZATION, ELECTROHYDRODYNAMIC ATOMIZATION, DRUG-DELIVERY, AEROSOL, LIQUIDS, ELECTROSPRAY, INHALATION, DEPOSITION
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Mechanical Engineering

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