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Exposing relationships using directed evolution

Miller, OJ; Dalby, PA; (2004) Exposing relationships using directed evolution. TRENDS BIOTECHNOL , 22 (5) 203 - 205. 10.1016/j.tibtech.2004.03.003.

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Abstract

Functionally related protein structures that have undergone significant mutagenesis and re-arrangement over a large evolutionary time-scale might no longer share enough sequence or structural similarity to be revealed by even the most advanced database searches. Recently, Christ and Winter used directed evolution to obtain functional variants of the RNA-hairpin-binding protein Rop. Using the functional sequences obtained, a structural database search revealed previously unknown similarity to the tRNA-binding region of valy- tRNA synthetase.

Type:Article
Title:Exposing relationships using directed evolution
DOI:10.1016/j.tibtech.2004.03.003
Keywords:IN-VITRO EVOLUTION, PHAGE DISPLAY, BETA-GLUCURONIDASE, BINDING-PROTEINS, ENZYME, AFFINITY, RECOGNITION, SPECIFICITY, STABILITY, LIBRARY
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering

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