Zhang, F; Ferretti, P; Clarke, JDW; (2003) Recruitment of postmitotic neurons into the regenerating spinal cord of urodeles. DEV DYNAM , 226 (2) 341 - 348. 10.1002/dvdy.10230.
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By using fluorescent tracers, we have investigated the origin of the cells that form the regenerating spinal cord after tail amputation in urodele amphibians. We show that spinal cord cells immediately adjacent to the amputation plane die and are removed by phagocytic cells. Spinal cells just anterior to these dying cells are destined to make the majority of the regenerating cord. The largest contribution is likely to come from the radial ependymal cells, but we also demonstrate that postmitotic neurons in this location can translocate into the regenerating cord. These neurons integrate into the regenerate structure and survive for at least 4 weeks. We find no evidence that these translocated neurons dedifferentiate and divide during this regeneration process. We discuss the possibility that these neurons survive long term in the regenerate cord and become part of the functional neuronal circuitry. (C) 2003 Wiley-Liss, Inc.
|Title:||Recruitment of postmitotic neurons into the regenerating spinal cord of urodeles|
|Keywords:||regeneration, spinal cord, urodele, axolotl, RADIAL GLIAL-CELLS, PERIPHERAL NERVOUS-SYSTEM, INTERMEDIATE FILAMENT, TAIL REGENERATION, VENTRICULAR ZONE, PRECURSOR CELLS, OPTIC TECTUM, IN-VIVO, PROLIFERATION, MIGRATION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Infection and Immunity > ICH - Molecular Immunology Unit
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health > Department of Neurosciences and Mental Health > ICH - Developmental Biology Unit
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