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Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase

Marson, CM; Rioja, AS; Brooke, G; Coombes, RC; Vigushin, DM; (2002) Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase. BIOORG MED CHEM LETT , 12 (2) 255 - 259.

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Abstract

Cyclic acid anhydrides possessing a lipid chain have been shown to be a new class of non-peptidic inhibitors of geranylgeranyl protein-transferase type I (GGPTase-I). (C) 2002 Elsevier Science Ltd. All rights reserved.

Type:Article
Title:Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase
Keywords:I INHIBITOR, FARNESYLTRANSFERASE INHIBITORS, PROTEIN GERANYLGERANYLATION, RAS PRENYLATION, K-RAS, GROWTH, FARNESYLATION, CELLS, TRANSFORMATION, REQUIRES
UCL classification:UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry

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