Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase.
BIOORG MED CHEM LETT
255 - 259.
Cyclic acid anhydrides possessing a lipid chain have been shown to be a new class of non-peptidic inhibitors of geranylgeranyl protein-transferase type I (GGPTase-I). (C) 2002 Elsevier Science Ltd. All rights reserved.
|Title:||Cyclic acid anhydrides as a new class of potent, selective and non-peptidic inhibitors of geranylgeranyl transferase|
|Keywords:||I INHIBITOR, FARNESYLTRANSFERASE INHIBITORS, PROTEIN GERANYLGERANYLATION, RAS PRENYLATION, K-RAS, GROWTH, FARNESYLATION, CELLS, TRANSFORMATION, REQUIRES|
|UCL classification:||UCL > School of BEAMS
UCL > School of BEAMS > Faculty of Maths and Physical Sciences
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