Observations on the enforced orthogonality concept for the synthesis of fully hindered biaryls by a tin-free intramolecular radical ipso substitution.
475 - 478.
Hindered biaryls have been simply prepared using diazonium salt precursors and an intramolecular free radical [1,5] ipso substitution protocol. The introduction of an additional substituent ortho to the diazonium group in the sigma aryl radical donor further enforces the formation of ipso substitution products and hence fully hindered biaryls are the favoured products.
|Title:||Observations on the enforced orthogonality concept for the synthesis of fully hindered biaryls by a tin-free intramolecular radical ipso substitution|
|Keywords:||radical reactions, biaryls, titanium trichloride, substituent, effects, ipso substitution, CROSS-COUPLING REACTIONS|
|UCL classification:||UCL > School of BEAMS > Faculty of Maths and Physical Sciences > Chemistry|
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