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ARF-regulated phospholipase D in membrane traffic

Jones, D; Morgan, CP; Cockcroft, S; (1999) ARF-regulated phospholipase D in membrane traffic. In: Thiery, JP, (ed.) UNSPECIFIED (85 - 108). I O S PRESS

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Abstract

It is now well-established that phospholipase D (PLD) is acutely stimulated upon activation by a wide range of cell-surface receptors. Over the last five years, tremendous effort has gone: to identify the major intracellular regulators of PLD and the cloning of PLD enzymes. In this chapter, we review the physiological function of mammalian phospholipase D1 (PLD1) activity that is synergistically stimulated by ADP-ribosylation factor (ARF), Rho and protein kinase C alpha. We discuss the function of this enzyme in vesicle formation and in regulated exocytosis.

Type: Book chapter
Title: ARF-regulated phospholipase D in membrane traffic
ISBN: 90-5199-494-X
Keywords: ADP-RIBOSYLATION-FACTOR, PROTEIN-KINASE-C, PHOSPHATIDYLINOSITOL TRANSFER PROTEIN, GTP-BINDING PROTEIN, GUANINE-NUCLEOTIDE-EXCHANGE, PLECKSTRIN-HOMOLOGY DOMAINS, NASCENT SECRETORY VESICLES, YEAST GOLGI-COMPLEX, HUMAN-NEUTROPHILS, SACCHAROMYCES-CEREVISIAE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/129105
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