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Level of action of cathodal DC polarisation induced inhibition of the human motor cortex

Nitsche, MA; Nitsche, MS; Klein, CC; Tergau, F; Rothwell, JC; Paulus, W; (2003) Level of action of cathodal DC polarisation induced inhibition of the human motor cortex. CLIN NEUROPHYSIOL , 114 (4) 600 - 604. 10.1016/S1388-2457(02)00412-1.

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Abstract

Objective: To induce prolonged motor cortical excitability reductions by transcranial direct current stimulation in the human.Methods: Cathodal direct current stimulation was applied transcranially to the hand area of the human primary motor cortex from 5 to 9 min in separate sessions in twelve healthy subjects. Cortico-spinal excitability was tested by single pulse transcranial magnetic stimulation. Transcranial electrical stimulation and H-reflexes were used to learn about the origin of the excitability changes. Neurone specific enolase was measured before and after the stimulation to prove the safety of the stimulation protocol.Results: Five and 7 min direct current stimulation resulted in motor cortical excitability reductions, which lasted for minutes after the end of stimulation, 9 min stimulation induced after-effects for up to an hour after the end of stimulation, as revealed by transcranial magnetic stimulation. Muscle evoked potentials elicited by transcranial electric stimulation and H-reflexes did not change. Neurone specific enolase concentrations remained stable throughout the experiments.Conclusions: Cathodal transcranial direct current stimulation is capable of inducing prolonged excitability reductions in the human motor cortex non-invasively. These changes are most probabely localised intracortically. (C) 2003 International Federation of Clinical Neurophysiology. Published by Elsevier Science Ltd. All rights reserved.

Type: Article
Title: Level of action of cathodal DC polarisation induced inhibition of the human motor cortex
DOI: 10.1016/S1388-2457(02)00412-1
Keywords: transcranial direct current stimulation, transcranial magnetic stimulation, motor cortex, neuroplasticity, cortical excitability, human, DIRECT-CURRENT STIMULATION, MAGNETIC STIMULATION, POLARIZING CURRENTS, CEREBRAL-CORTEX, EXCITABILITY, ACTIVATION, MODULATION, MIGRAINE, BRAIN, RAT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/128757
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