UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Current Developments and Future Prospects for Heart Valve Replacement Therapy

Kidane, AG; Burriesci, G; Cornejo, P; Dooley, A; Sarkar, S; Bonhoeffer, P; Edirisinghe, M; (2009) Current Developments and Future Prospects for Heart Valve Replacement Therapy. J BIOMED MATER RES B , 88B (1) 290 - 303. 10.1002/jbm.b.31151.

Full text not available from this repository.

Abstract

Valve replacement is the most common surgical treatment in patients with advanced valvular heart disease. Mechanical and bio-prostheses have been the traditional heart valve replacements in these patients. However, currently the heart valves for replacement therapy are imperfect and subject patients to one or more ongoing risks, including thrombosis, limited durability. and need for re-operations due to the lack of growth in pediatric populations. Furthermore, they require an open heart surgery, which is risky for elderly and young children Who are too weak or ill to undergo major surgery. This article reviews the current state of the art of heart valve replacements in light of their potential clinical applications. In recent years polymeric materials have been widely studied as potential prosthetic heart valve material being designed to overcome the clinical problems associated with both mechanical and bio-prosthetic valves. The review also addresses the advances in polymer materials, tissue engineering approaches, and the development of percutaneous valve replacement technology and discusses the future prospects in these fields. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 88B: 290-303, 2009

Type: Article
Title: Current Developments and Future Prospects for Heart Valve Replacement Therapy
DOI: 10.1002/jbm.b.31151
Keywords: heart valve replacement, polymers, tissue engineering, percutaneous heart valves, POLY(ETHER URETHANE) BIODEGRADATION, CALCIFIC AORTIC-STENOSIS, MESENCHYMAL STEM-CELLS, IN-VIVO BIOSTABILITY, BONE-MARROW-CELLS, PULMONARY VALVE, SILSESQUIOXANE NANOCOMPOSITES, POLY(CARBONATE URETHANE), POLYURETHANE TRILEAFLET, BIOMEDICAL APPLICATIONS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: http://discovery.ucl.ac.uk/id/eprint/128642
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item