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Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans

Baumer, T; Lange, R; Liepert, J; Weiller, C; Siebner, HR; Rothwell, JC; Munchau, A; (2003) Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans. NEUROIMAGE , 20 (1) 550 - 560. 10.1016/S1053-8119(03)00310-0.

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Abstract

We explored the aftereffects of two premotor 1 Hz rTMS sessions on motor cortex excitability in healthy humans. In experiment 1, 11 healthy right-handed volunteers received 20-min submotor threshold I Hz rTMS trains over the left premotor cortex on 2 consecutive days. Left motor cortex excitability was determined at baseline, immediately after, 30, 60, 120 min, and 24 h after each rTMS session. We measured motor thresholds, amplitudes of motor-evoked potentials, silent periods, and paired-pulse excitability at interstimulus intervals (ISI) of 3-7, 10, and 15 ms. In experiment 2, 5 volunteers received two identical rTMS trains on Days 1 and 7. Measurements were carried out on Day I (first rTMS train), Day 2, and Day 7 (second rTMS train). In experiment I there was a selective increase of paired pulse facilitation at an ISI of 7 ms after rTMS lasting for less than 30 min on Day 1. This effect was also present after rTMS on Day 2. However, it persisted for at least 2 h. In experiment 2 the same extra facilitation was induced by rTMS on Days I and 7 but not on Day 2. It lasted for less than 30 min on both Day I and Day 7. We conclude that I Hz premotor rTMS leads to cumulative plastic changes of intrinsic motor cortex excitability when repeated within 24 h but not after 1 week, implying the formation of memory after the first rTMS train lasting more than a day but less than a week. (C) 2003 Elsevier Inc. All rights reserved.

Type: Article
Title: Repeated premotor rTMS leads to cumulative plastic changes of motor cortex excitability in humans
DOI: 10.1016/S1053-8119(03)00310-0
Keywords: TRANSCRANIAL MAGNETIC STIMULATION, LONG-TERM POTENTIATION, CORTICOCORTICAL INHIBITION, CORTICOSPINAL EXCITABILITY, CORTICAL EXCITABILITY, BRAIN-STIMULATION, COIL ORIENTATION, AREA CA1, DEPRESSION, HIPPOCAMPUS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/128592
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