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NEW INSIGHTS INTO THE CAUSE OF PARKINSONS-DISEASE

JENNER, P; SCHAPIRA, AHV; MARSDEN, CD; (1992) NEW INSIGHTS INTO THE CAUSE OF PARKINSONS-DISEASE. NEUROLOGY , 42 (12) 2241 - 2250.

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Abstract

Current concepts as t,o the cause of Parkinson's disease (PD) suggest an inherited predisposition to environmental or endogenous toxic agents. Study of the substantia nigra after death in PD has highlighted three major changes: (1) evidence of oxidative stress and depletion of reduced glutathione; (2) high levels of total iron, with reduced ferritin buffering; and (3) mitochondrial complex I deficiency. Which of these is the primary event, generating a secondary cascade of changes culminating in nigral cell death, is unknown. In presymptomatic Lewy body-positive control brains, the nigra shows depletion of reduced glutathione content and, possibly, a reduction of complex I activity. Whatever the significance of these various abnormalities, be they causal or secondary, they provide novel targets for the development, of new strategies to treat the cause of PD.

Type: Article
Title: NEW INSIGHTS INTO THE CAUSE OF PARKINSONS-DISEASE
Keywords: ENVIRONMENTAL RISK-FACTORS, COMPLEX-I DEFICIENCY, ELECTRON-TRANSPORT CHAIN, 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE MPTP, MONOAMINE-OXIDASE, SUBSTANTIA-NIGRA, MITOCHONDRIAL RESPIRATION, BRAIN MITOCHONDRIA, 1-METHYL-4-PHENYLPYRIDINIUM ION, TYROSINE-HYDROXYLASE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/128483
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