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Opinion - Will telomere erosion lead to a loss of T-cell memory?

Akbar, AN; Beverley, PCL; Salmon, M; (2004) Opinion - Will telomere erosion lead to a loss of T-cell memory? NAT REV IMMUNOL , 4 (9) 737 - 743. 10.1038/nri1440.

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Abstract

Evidence is accumulating that elderly individuals are more susceptible to infection with organisms to which they were previously immune. This indicates that there might be a limit to the persistence of immune memory. This fact is particularly disturbing because the average life expectancy of humans has almost doubled in the past 200 years and is still increasing. We discuss mechanisms that might constrain the persistence of memory T cells and consider whether humans will suffer from memory T-cell exhaustion as life expectancy increases.

Type: Article
Title: Opinion - Will telomere erosion lead to a loss of T-cell memory?
DOI: 10.1038/nri1440
Keywords: IN-VIVO, CYTOMEGALOVIRUS SEROPOSITIVITY, LYMPHOCYTE SUBPOPULATIONS, DYSKERATOSIS-CONGENITA, REVERSE-TRANSCRIPTASE, PERSISTENT VIRUS, VACCINIA VIRUS, LONG TELOMERES, OLDER-PEOPLE, AGED HUMANS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: http://discovery.ucl.ac.uk/id/eprint/128314
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