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The after-effect of human theta burst stimulation is NMDA receptor dependent

Huang, YZ; Chen, RS; Rothwell, JC; Wen, HY; (2007) The after-effect of human theta burst stimulation is NMDA receptor dependent. CLIN NEUROPHYSIOL , 118 (5) 1028 - 1032. 10.1016/j.clinph.2007.01.021.

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Abstract

Objective: To provide pharmacological evidence that the after-effects of theta burst stimulation (TBS) involve plasticity like changes in cortical synaptic connections, using the N-methyl-D-aspartate receptor antagonist memantine.Methods: We performed a double blind, placebo-controlled study to evaluate the effect of memantine on the response of six healthy volunteers to TBS. We measured rest (RMT) and active (AMT) motor thresholds, and the amplitude of MEPs before and after continuous and intermittent TBS (cTBS/iTBS) after the administration of placebo or memantine.Results: Memantine had no effect on RMT and AMT, while it blocked the suppressive effect of cTBS and the facilitatory effect of iTBS.Conclusions: The effects of iTBS and cTBS rely on NMDARs to produce after-effects in the motor cortex of conscious humans.Significance: The NMDA dependency of the after-effects of TBS adds to the understanding of the underlying mechanism of TBS, and suggests that these after-effects are likely to involve plasticity like changes at synaptic connections in motor cortex. (c) 2007 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: The after-effect of human theta burst stimulation is NMDA receptor dependent
DOI: 10.1016/j.clinph.2007.01.021
Keywords: transcranial magnetic stimulation, theta burst stimulation, N-methyl-D-aspartate, plasticity, long-term potentiation, long-term depression, HUMAN MOTOR CORTEX, LONG-TERM POTENTIATION, ANTAGONIST MEMANTINE, EXCITABILITY, MECHANISMS, RAT, AMANTADINE, DEPRESSION, NEURONS, SLICES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/128072
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